calming toddlers

“My 2yo has started crying a LOT the past few days. Over every little thing. Nothing is different physically or environmentally that I can tell. He already has his 2yo molars, too.. He’s just been crying about everything that he doesn’t like, with some pretty good tantrums thrown in the mix of the average crying. I tried holding him in timeout (he’s never stayed in time out on his own so far), but he screamed and threw a serious tantrum the whole time.. which wouldn’t be a problem for me except that I have to take care of the other kids, too! I tried holding him in our time-out spot until he was done with the tantrum so I could praise him for being happy, etc., but after 40 minutes of continuous screaming, my baby was also crying, needing to be fed, and the other young kids had destroyed the basement. At that point I just took him to his bed to finish his crying fit. So I’m thinking the holding in time out option might not work for us. Yesterday and today I’ve started just taking him to his room when he starts having a breaking down crying fit. What would you suggest? Do you think I should just take him to his room every time he cries? Or should I try